MovDisordV3, Main, Exploration, bibRecord, 003311

Nonsteroidal anti‐inflammatory drugs and risk of Parkinson's disease

Identifieur interne : 003311 ( Main/Exploration ); précédent : 003310; suivant : 003312

Nonsteroidal anti‐inflammatory drugs and risk of Parkinson's disease

Auteurs : Thanh G. Ton [États-Unis] ; Susan R. Heckbert [États-Unis] ; W. T. Longstreth Jr. [États-Unis] ; Mary Anne Rossing [États-Unis] ; Walter A. Kukull [États-Unis] ; Gary M. Franklin [États-Unis] ; Phillip D. Swanson [États-Unis] ; Terri Smith-Weller [États-Unis] ; Harvey Checkoway [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-07.

RBID : ISTEX:D8CE3A218198D995E290A58653036C4A21D91D69

Descripteurs français

Pascal (Inist)
- Acétylsalicylique acide, Antiinflammatoire non stéroïde, Facteur risque, Inflammation, Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Acetylsalicylic acid, Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal (administration & dosage), Aspirin (administration & dosage), Case-Control Studies, Cross-Sectional Studies, Female, Humans, Ibuprofen (administration & dosage), Inflammation, Male, Middle Aged, NSAIDs, Nervous system diseases, Non steroidal antiinflammatory agent, Odds Ratio, Oxidative Stress (drug effects), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Parkinson Disease (prevention & control), Parkinson disease, Parkinson's disease, Retrospective Studies, Risk, Risk factor, Washington, aspirin, inflammation, nonsteroidal anti‐inflammatory drugs.
MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Ibuprofen.
- geographic : Washington.
- diagnosis : Parkinson Disease.
- drug effects : Oxidative Stress.
- epidemiology : Parkinson Disease.
- prevention & control : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Odds Ratio, Retrospective Studies, Risk.

Abstract

Inflammation and oxidative stress have been implicated as pathogenic mechanisms in Parkinson's disease (PD). Evidence from in vitro and animal studies suggests a possible protective role of nonsteroidal anti‐inflammatory drugs (NSAIDs), including aspirin. We investigated the risk of PD associated with use of aspirin and nonaspirin NSAIDs in a population‐based case‐control study among enrollees of Group Health Cooperative, a health maintenance organization in the Seattle area. Subjects included 206 cases between ages 35 and 89 with a new diagnosis of idiopathic PD between 1992 and 2002, and 383 randomly selected controls frequency‐matched by age, sex, duration of enrollment, and clinic. We obtained information on participants' age, smoking, and medical history from interview. Exposure to NSAIDs was ascertained from an automated pharmacy database. Medications filled within 5 years of the interview were excluded. After adjusting for age, sex, smoking, duration of enrollment, and clinic, the risk of PD among individuals who received nonaspirin NSAIDs between 1977 and 1992 was 0.90 (95% CI: 0.59–1.35) and 1.67 (95% CI: 0.60–4.60) between 1993 and 2002. Use of ibuprofen was not associated with PD (OR: 0.89; 95% CI: 0.60–1.32). The risk of PD associated with aspirin or aspirin‐containing medications was 0.74 (95% CI: 0.49–1.12). We observed no trend in risk according to number of fills for these drugs. Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/D8CE3A218198D995E290A58653036C4A21D91D69/fulltext/pdf

DOI: 10.1002/mds.20856

Affiliations:

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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)</term>
<term>Aspirin (administration & dosage)</term>
<term>Case-Control Studies</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Ibuprofen (administration & dosage)</term>
<term>Inflammation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>NSAIDs</term>
<term>Nervous system diseases</term>
<term>Non steroidal antiinflammatory agent</term>
<term>Odds Ratio</term>
<term>Oxidative Stress (drug effects)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (prevention & control)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Retrospective Studies</term>
<term>Risk</term>
<term>Risk factor</term>
<term>Washington</term>
<term>aspirin</term>
<term>inflammation</term>
<term>nonsteroidal anti‐inflammatory drugs</term>
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<term>Aspirin</term>
<term>Ibuprofen</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term>
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<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Retrospective Studies</term>
<term>Risk</term>
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<term>Antiinflammatoire non stéroïde</term>
<term>Facteur risque</term>
<term>Inflammation</term>
<term>Parkinson maladie</term>
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<front><div type="abstract" xml:lang="en">Inflammation and oxidative stress have been implicated as pathogenic mechanisms in Parkinson's disease (PD). Evidence from in vitro and animal studies suggests a possible protective role of nonsteroidal anti‐inflammatory drugs (NSAIDs), including aspirin. We investigated the risk of PD associated with use of aspirin and nonaspirin NSAIDs in a population‐based case‐control study among enrollees of Group Health Cooperative, a health maintenance organization in the Seattle area. Subjects included 206 cases between ages 35 and 89 with a new diagnosis of idiopathic PD between 1992 and 2002, and 383 randomly selected controls frequency‐matched by age, sex, duration of enrollment, and clinic. We obtained information on participants' age, smoking, and medical history from interview. Exposure to NSAIDs was ascertained from an automated pharmacy database. Medications filled within 5 years of the interview were excluded. After adjusting for age, sex, smoking, duration of enrollment, and clinic, the risk of PD among individuals who received nonaspirin NSAIDs between 1977 and 1992 was 0.90 (95% CI: 0.59–1.35) and 1.67 (95% CI: 0.60–4.60) between 1993 and 2002. Use of ibuprofen was not associated with PD (OR: 0.89; 95% CI: 0.60–1.32). The risk of PD associated with aspirin or aspirin‐containing medications was 0.74 (95% CI: 0.49–1.12). We observed no trend in risk according to number of fills for these drugs. Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs. © 2006 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Nonsteroidal anti‐inflammatory drugs and risk of Parkinson's disease

Nonsteroidal anti‐inflammatory drugs and risk of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.